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2. Degree of Substitution (DS) The DS refers to the average number of hydroxyl groups replaced by hydroxyethyl groups. A higher DS typically enhances water solubility because the ether groups disrupt the hydrogen-bonding network of the cellulose, making it easier for the polymer chains to interact with water molecules.
hydroxyethyl cellulose solubility

4. Geopolitical Factors Global dynamics and trade policies also play a role in HPMC pricing. Tariffs, trade agreements, and political stability in key production regions can either hinder or promote the availability of HPMC powder internationally. Additionally, regions facing economic crises may experience inflation that impacts HPMC prices.
hpmc powder price
