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Several antihistamines have been tested in veterinary medicine, but their effectiveness in horses specifically requires careful consideration. Common antihistamines like diphenhydramine and chlorpheniramine are known to be safe for equine use. However, the effectiveness in reducing the symptoms associated with heaves remains variable. Some studies have shown that antihistamines can provide mild relief in certain cases, especially when used as an adjunct to other treatments. This particularly applies when the condition is linked to a clear allergic response.
antihistamine for horses with heaves

MSM (Methylsulfonylmethane), while not an herb in the traditional sense, is a naturally occurring compound often included in herbal joint supplements. MSM is known for its anti-inflammatory properties and its ability to improve overall joint function. Many horse owners find that supplementing with MSM can lead to improved flexibility and reduced stiffness.
herbal joint supplements for horses
