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In pharmaceutical applications, HPMC is frequently utilized as a film-forming agent, thickener, and stabilizer in drug formulations. The glass transition temperature plays a vital role in determining the stability and release profile of the drug. For instance, if HPMC is used in a controlled-release formulation, knowing its Tg can help in predicting how the polymer will behave at different temperatures. A Tg that is significantly lower than the storage temperature may indicate a risk of the polymer transitioning to a rubbery state, which could lead to premature release of the active ingredient.
hpmc glass transition temperature
